Proteasome-guided haem signalling axis contributes to T cell exhaustion - Nature

Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10250-yExhausted CD8+ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.